Divided into compartments with a platform in the middle, the horizontal electrophoresis systems completely submerge plated gel platforms in a buffer. In each compartment, electrodes produce the electric field to cause molecules to travel through the casted gel for DNA and RNA fragment separation. Capable of simultaneously running multiple samples, the equipment recirculates buffer efficiently to prevent ionic gradient formation. The high-throughput horizontal electrophoresis systems include color-coding combs and strips for easy loading.